| 8:08:36 PM - Thu, Aug 8th 2024 |
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Yes, Fildena 100 mg, which contains Sildenafil Citrate, can interact with certain other prescription drugs. These interactions can affect how Fildena works or increase the risk of side effects. Here are some key drug interactions to be aware of: 1. Nitrates: Serious Interaction: Fildena should not be taken with nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate), which are often prescribed for chest pain (angina). The combination can cause a dangerous drop in blood pressure, leading to severe cardiovascular issues, including fainting or heart attack. 2. Alpha-Blockers: Blood Pressure Interaction: Alpha-blockers (e.g., doxazosin, tamsulosin), used to treat high blood pressure or prostate conditions, can also lower blood pressure. When combined with Fildena, there is a risk of hypotension (low blood pressure), which could cause dizziness or fainting. Your healthcare provider may adjust the timing or dosage to minimize this risk. 3. Antihypertensives: Cumulative Effects: Other blood pressure medications, such as beta-blockers, ACE inhibitors, or calcium channel blockers, may have additive blood pressure-lowering effects when taken with Fildena. Careful monitoring and possible dosage adjustments are necessary. 4. CYP3A4 Inhibitors: Increased Sildenafil Levels: Medications that inhibit the CYP3A4 enzyme, like certain antifungals (ketoconazole), antibiotics (erythromycin), or HIV protease inhibitors (ritonavir), can increase the level of Sildenafil in your blood, raising the risk of side effects such as headache, dizziness, or low blood pressure. A lower dose of Fildena may be recommended in such cases. 5. Other Erectile Dysfunction Medications: Overdose Risk: Taking Fildena with other medications for erectile dysfunction (e.g., Tadalafil, Vardenafil) can lead to an overdose, increasing the likelihood of severe side effects, such as prolonged erections (priapism), low blood pressure, or severe headaches. 6. Certain Antidepressants and Mood Stabilizers: Serotonin Syndrome Risk: If combined with certain antidepressants, particularly SSRIs or SNRIs, there might be an increased risk of serotonin syndrome, although this is rare. The interaction should still be evaluated by a healthcare provider. 7. Antibiotics and Antifungals: Effect on Drug Metabolism: Some antibiotics and antifungals can affect the metabolism of Sildenafil, potentially increasing its effects and side effects. The doctor may need to adjust the dose of Fildena. 8. Alcohol: Increased Side Effects: While not a prescription drug, alcohol can interact with Fildena, potentially enhancing its blood pressure-lowering effects and increasing the likelihood of dizziness, headaches, or fainting. 9. Medications for Pulmonary Arterial Hypertension (PAH): Risk of Severe Interactions: Sildenafil is also used in some cases to treat PAH (e.g., Revatio). Taking Fildena along with other PAH medications can increase the risk of serious side effects and should be avoided unless specifically prescribed by a doctor. 10. Grapefruit Juice: Increased Drug Levels: Although not a medication, grapefruit juice can interfere with the metabolism of Sildenafil, potentially leading to higher levels in the blood and an increased risk of side effects.
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